Replying to a message from: Pie

I currently have inbound messaging working (Internet -> Xeams -> local SMTP Server). However tryin to get Xeams to send messages to the internet that it received from the local SMTP server is resulting in the below error:

Failure reason: No server listening on port 25

 

I can not setup specific ports for every domain on the internet that users may send email too. So in this case, how will Xeams route emails to the internet?