Mail stuck in outbound queue Melvin

From: Melvin
Date: 11/2/16 6:21 AM
Topic: Mail stuck in outbound queue
Type: Installation
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We're new to Xeams and installed this yesterday, some outgoing messages work, but now most of them fail and are stuck in the queue.

We are using a smarthost, and when retrying we receive the Error: Unable to connect to remote SMTP server. Exception reading response.


Any idea how we can fix this?